HPE Proliant DL385 Gen10 Plus

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HPE Proliant DL385 Gen10 Plus

Do you need a dense platform with built-in security and flexibility that addresses key applications such as virtualization, software-defined storage (SDS), and High-Performance Compute (HPC)?

Building on HPE ProLiant as the intelligent foundation for hybrid cloud, the HPE ProLiant DL385 Gen10 Plus server offers the 2nd generation AMD® EPYC™ 7000 Series processor delivering up to 2X1 the performance of the prior generation. With up to 128 cores (per 2-socket configuration), 32 DIMMs for memory up to 3200 MHz, the HPE ProLiant DL385 Gen10 Plus server delivers low cost virtual machines (VMs) with unprecedented security. Equipped with PCIe Gen4 capabilities, HPE ProLiant DL385 Gen10 Plus offers improved data transfer rates and higher networking speeds. Combined with a better balance of processor cores, memory and I/O makes the HPE ProLiant DL385 Gen10 Plus the ideal choice for virtualization, and memory-intensive and HPC workloads.

What's New

  • Powered by the 2nd generation AMD® EPYC™ 7000 Series processor with double2 the core density compared to the previous generation.
  • Higher bandwidth and improved data transfer rates with PCIe Gen4 capabilities.
  • Faster application performance with increased memory speeds up to 3200 MT/s.
  • HPE InfoSight provides a cloud-based analytics tool that predicts and prevents problems before your business is impacted.

[1] Comparing the HPE ProLiant DL385 Gen10 Plus with AMD EPYC™ 7702 processor versus the AMD EPYC™ 7601P processor, and based on SPECrate2017_int_base score results. SPEC and the names SPEC CPU and SPECrate are registered trademarks of the Standard Performance Evaluation Corporation (SPEC), see spec.org

[2] The first generation AMD EPYC processor offered up to 32 cores while the second generation AMD EPYC processor offers up to 64 cores.

Key Features

Flexible Design

The HPE ProLiant DL385 Gen10 Plus server has an adaptable chassis, including the modular drive bays that can be configured with up to 28 SFF, up to 20 LFF, or up to 16 NVMe drive options

The redesigned HPE Smart Array Essential and Performance RAID Controllers offer performance and flexibility for additional features including the ability to operate in both SAS and HBA mode.

Choice of OCP 3.0 or PCIe standup adapters which offers a choice of networking bandwidth and fabric, making it scalable for changing business needs.

The HPE ProLiant DL385 Gen10 Plus supports a wide range of operating systems, making it suitable for most environments.


The HPE ProLiant DL385 Gen10 Plus server features HPE iLO 5 which monitors servers for ongoing management, service alerting, reporting, and remote management to resolve issues quickly and keep your business running from anywhere in the world.

HPE OneView is an automation engine that transforms compute, storage, and networking into software-defined infrastructure to automate tasks and speed business process implementations.

HPE InfoSight provides built-in AI that predicts problems before they happen, proactively resolves issues, and continually learns as it analyzes data—making every system smarter and more reliable.

HPE iLO RESTful API feature provides iLO RESTful API extensions to Redfish, allowing you to take full advantage of the wide range of value-added API features and integrate easily with leading orchestration tools.


The HPE ProLiant DL385 Gen10 Plus server is built with Silicon Root of Trust as an immutable fingerprint in the iLO silicon. The silicon root of trust validates the lowest level firmware to BIOS and software to verify a known good state.

Tied into the silicon root of trust is the AMD Secure Processor, a dedicated security processor embedded in the AMD EPYC system on a chip (SoC). The security processor manages secure boot, memory encryption, and secure virtualization.

Run Time Firmware Validation validates the iLO and UEFI/BIOS firmware at runtime. Notification and automated recovery is executed on detection of compromised firmware.

If system corruption has been detected, Server System Restore will automatically alert iLO Amplifier Pack to initiate and manage the system recovery process, avoiding lasting damage to your business by quickly restoring firmware to the factory settings or the last known authenticated safe setting.


The HPE ProLiant DL385 Gen10 Plus server supports HPE Right Mix Advisor to provide data-driven guidance and drive the ideal hybrid cloud mix for workloads, allowing for intelligent planning, speeding migrations from months to weeks, and controlling the cost of migration.

HPE GreenLake Flex Capacity provides pay-per-use IT consumption on-premises with real-time tracking and metering of resource usage, so you have the capacity you need to deploy quickly, pay for the exact resources you consume, and avoid over provisioning.

HPE Foundation Care helps when there is a hardware or software problem, offering several response levels dependent on IT and business requirements.

HPE Proactive Care is an integrated set of hardware and software support including an enhanced call experience with start to finish case management, helping resolve incidents quickly and keeping IT reliable and stable.

HPE Financial Services helps you transform to a digital business with financing options and trade-in opportunities that align to your business goals.

Product Images

Technical Specifications

Processor TypeAMD
Processor Family2nd Generation AMD EPYC™ 7000 Series
Processor Core Available64 or 48 or 32 or 24 or 16 or 8, per processor, depending on model
Processor Cache Installed256 MB or 192 MB or 128 MB L3, per processor , depending on model
Maximum Memory4.0 TB with 128 GB DDR4 [2]
Memory Slots32
Memory TypeHPE DDR4 Smart Memory
Memory Protection FeaturesECC
Drive Supported8 or 12 LFF SAS/SATA/SSD with 4 LFF rear drive optional and and 2 SFF rear drive optional 8 or 24 SFF SAS/SATA/SSD with 4 SFF rear drive optional, 16 SFF NVMe Front bay
Network ControllerChoice of optional OCP plus standup, depending on model
System Fan FeaturesHot-plug redundant fans, standard
Power Supply Type2 Flexible Slot power supplies, maximum depending on model
Expansion Slots8 maximum
Storage Controller1 HPE Smart Array P408i-a and/or 1 HPE Smart Array P816i-a and/or 1 HPE Smart Array E208i-a (depending on model) etc
Warranty Standard StatementServer Warranty includes 3-years parts, 3-years labor, 3-years on-site support with next business day response. Additional information regarding worldwide limited warranty and technical support is available at: www.hpe.com/services/support. Additional Hewlett Packard Enterprise support and service coverage for your product can be purchased locally. For information on availability of service upgrades and the cost for these service upgrades, refer to www.hpe.com/services/support.
Processor NameAMD EPYC™ 7000 Series
Processor NumberUp to 2
Processor Speed3.4 GHz maximum, depending on processor
Standard Memory4 TB with 32 x 128 GB RDIMMs
Form Factor2U
Weight (imperial)33.25 lb
Weight (metric)15.1 kg
Product Dimensions (imperial)3.44 x 17.54 x 29.5 in
Product Dimensions (metric)8.73 x 44.54 x 74.9 cm

Pre-configured Models

Part NumberModel Name
P07594-B21HPE ProLiant DL385 Gen10 Plus 7262 3.2GHz 8-core 1P 16GB-R 8LFF 500W PS Server
P07595-B21HPE ProLiant DL385 Gen10 Plus 7262 3.2GHz 8-core 1P 16GB-R 8SFF 500W PS Server
P07596-B21HPE ProLiant DL385 Gen10 Plus 7302 3.0GHz 16-core 1P 32GB-R 8SFF 500W PS Server
P07597-B21HPE ProLiant DL385 Gen10 Plus 7702 2.0GHz 64-core 1P 32GB-2R 24SFF 800W PS Server
P07598-B21HPE ProLiant DL385 Gen10 Plus 7402 2.8GHz 24-core 2P 32GB-R 16SFF NVMe 800W PS Server

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